S. cerevisiae is one of the best studied microbes due to its industrial importance and its use as a eukaryotic model organism. The study of how wild S. cerevisiae strains evolved into greatly adapted domesticated strains and changed its lifestyle drastically, is still of great interest. In the case of wine yeasts populations, strains have accumulated numerous hallmarks of domestication, improving their adaptation to wine fermentation. Here, we explored the paradoxical population distribution of the two alleles described in IRC7, a β-lyase enzyme involved in the production of pleasant volatile thiols in wines. Interestingly, a truncated allele of IRC7 (coding a less functional Irc7p enzyme) has been fixed in wine yeast populations. Those interested in yeasts eco & evo, read the full story!