Scientific works published in the last 5 years:


  • Javier Vicente, Eva Navascués, Santiago Benito, Domingo Marquina, Antonio Santos. Microsatellite typing of Lachancea thermotolerans for wine fermentation monitoring. International Journal of Food Microbiology. 2023. 110186. doi:


  • Javier Vicente, Niina Kelanne, Eva Navascués, Fernando Calderón, Antonio Santos, Domingo Marquina, Baoru Yang, Santiago Benito. Combined use of Schizosaccharomyces pombe and Lachancea thermotolerans strain with high malic acid consumption ability for wine production. Fermentation. 2023. doi: 10.3390/ fermentation9020165
  • Javier Vicente, Javier Ruiz, SandraTomasi, Miguel de Celis, Candela Ruiz-de-Villa Jordi Gombau, Nicolás Rozès, Fernando Zamora, Antonio Santos, Domingo Marquina, Ignacio Belda. Impact of rare yeasts in Saccharomyces cerevisiae wine fermentation performance: population prevalence and growth phenotype of Cyberlindnera fabianii, Kazachstania unispora, and Naganishia globosaFood Microbiology. 2023. 110, 104189. doi: 10.1016/


o   Vicente, J.; Kelanne, N.; Rodrigo-Burgos, L.; Navascués, E.; Calderón, F.; Santos, A.; Marquina, D.; Yang, B.; Benito, S. Influence of different Lachancea thermotolerans strains in the wine profile in the era of climate challenge. FEMS Yeast Research. 2022. foac062. doi: 10.1093/femsyr/foac062

o   Pucciarelli S, Sparvoli D, Ballarini P, Piersanti A, Mozzicafreddo M, Arregui L, Miceli C. Ciliate Microtubule Diversities: Insights from the EFBTU3 Tubulin in the Antarctic Ciliate Euplotes focardii. Microorganisms. 2022; 10(12):2415. doi: 10.3390/microorganisms10122415

o   de Celis, M., Ruiz, J., Vicente, J., Acedo, A., Marquina, D., Santos, A., Belda, I. Expectable diversity patterns in wine yeast communities.  FEMS yeast Research. 2022. 22(1):foac034. doi: 10.1093/femsyr/foac034

o   Sánchez-Palencia, Y., Bolonio, D., Ortega, M.F., García-Martínez, M.J., Ortiz, J.E., Rayo, F., Arregui, L., Serrano, S., Llamas J. F. & Canoira L. 2022. Iron Removal from Kaolin Waste Dumps by Chemical (Oxalic and Citric Acids) and Biological (Bacillus Strain) Leaching. Clays and Clay Minerals. 70, 386–404. doi: 10.1007/s42860-022-00192-7

o   Javier Vicente, Yasemin Baran, Eva Navascués, Antonio Santos, Fernando Calderón, Domingo Marquina, Doris Rauhut, Santiago Benito. Biological management of acidity in wine industry: A review. International Journal of Food Microbiology. 2022. 375,109726. doi:10.1016/j.ijfoodmicro.2022.109726

o   de Celis M, Duque J, Marquina D, Salvadó H, Serrano S, Arregui L, Santos A, Belda I. Niche differentiation drives microbial community assembly and succession in full-scale activated sludge bioreactors. npj Biofilms and Microbiomes. 2022. 8:23 doi: 10.1038/s41522-022-00291-2

o   Gobbi A, Acedo A, Imam N, Santini RG, Ortiz-Álvarez R, Ellegaard-Jensen L, Belda I*, Hansen LH*. A global microbiome survey of vineyard soils highlights the microbial dimension of viticultural terroirs. Communications Biology. 2022. 5:241. doi: 10.1038/s42003-022-03202-5 (*co-supervision)

o   de Celis, M; Belda, I; Marquina, D. and Santos A. Phenotypic and transcriptional study of the antimicrobial activity of silver and zinc oxide nanoparticles on a wastewater biofilm-forming Pseudomonas aeruginosa strain. Science of the Total Environment. 2022. 826: 153915. doi:

o   Taladrid D, de Celis M, Belda I, Bartolomé B, Moreno-Arribas MV. Hypertension- and glycaemia-lowering effects of a grape-pomace-derived seasoning in patients and healthy volunteers. Interplay with the gut microbiome. Food & Function. 2022. 13, 2068.  doi:


o   N. Cheviron, V. Grondin, C. Marrauld, F. Poiroux, I. Bertrand, J. Abadie, P. Pandard, W. Riah-Anglet, C. Dubois, S. Malý, C.R. Marques, I. Valverde, A. Alonso, D. Marquina, C. Mougin. Inter-laboratory validation of an ISO test method for measuring enzyme activities in soil samples using colorimetric substrates. Environ Sci Pollut Res Int. 2021 doi: 10.1007/s11356-021-17173-3.

o   Javier Vicente, Eva Navascués, Fernando Calderón, Antonio Santos, Domingo Marquina, Santiago Benito. An Integrative View of the Role of Lachancea thermotolerans in Wine Technology. Foods. 2021. 10, 2878. doi:

o   Imam N, Belda I, García-Jiménez B, Duehl AJ, Doroghazi JR, Almonacid DE, Thomas VP, Acedo A. Local Network Properties of Soil and Rhizosphere Microbial Communities in Potato Plantations Treated with a Biological Product Are Important Predictors of Crop Yield. mSphere. 2021. e0013021. doi: 10.1128/mSphere.00130-21.

o   de Celis M, Serrano-Aguirre, L, Belda I, Liébana-García R, Arroyo M, Marquina D, de la Mata I, Santos A. Acylase enzymes disrupting quorum sensing alter the transcriptome and phenotype of Pseudomonas aeruginosa and the composition of bacterial biofilms from wastewater treatment plants. Science of the Total Environment. 2021. 799: 149401 doi: 10.1016/j.scitotenv.2021.149401.

o   Vicente J, de Celis M, Alonso A, Marquina D, Santos A. Microbial Communities Present in Hydrothermal Sediments from Deception Island, Antarctica. Microorganisms. 2021. 9, 1631. doi: 10.3390/microorganisms9081631.

o   Ruiz J, de Celis M, Martín-Santamaría M, Benito-Vázquez I, Pontes A, Lanza VF, Sampaio JP, Santos A, Belda I. Global distribution of IRC7 alleles in Saccharomyces cerevisiae populations: a genomic and phenotypic survey within the wine clade. Environmental Microbiology. 2021. 23(6) p. 3182-3195. doi: 10.1111/1462-2920.15540.

o   Ortiz-Álvarez R, Ortega-Arranz H, Ontiveros VJ, de Celis M., Ravarani C, Acedo A, Belda I. Network properties of local fungal communities reveal the anthropogenic disturbance consequences of farming practices in vineyard soils. mSystems. 2021. 6(3):e00344-21. doi: 10.1128/mSystems.00344-21.

o   Belda I, Cueva C, Tamargo A, Ravarani C, Acedo A, Bartolomé B, Moreno-Arribas MV. A multi-omics approach for understanding the effects of moderate wine consumption on human intestinal health . Food & Function. 2021. 12: 4152-4164 doi:

o   Ignacio Belda, Thomas C. Williams, Miguel de Celis, Ian T. Paulsen & Isak S. Pretorius. Seeding the idea of encapsulating a representative synthetic metagenome in a single yeast cell. Nature Communications. 2021. 12:1599. doi: 10.1038/s41467-021-21877-y.

o   Javier Vicente, Fernando Calderón, Antonio Santos, Domingo Marquina and Santiago Benito. High potential of Pichia kluyveri and other Pichia species in wine technology. International Journal of Molecular Science. 2021. 22:1196. doi: 10.3390/ijms22031196.

o   Pérez-Magariño, S., Cano-Mozo, E. Albors, C., Santos, A., Navascués, E. Autochtonous Oenococcus oeni strain to avoid histamine formation in red wines: A study in real winemaking conditions. American Journal of Enology and Viticulture. 2021. doi: 10.5344/ajev.2020.20010.

o   Benito-Vázquez, I., Belda, I., Ruiz, J., Vicente, J., Navascués, E., Marquina, D., Santos, A. Direct detection of Brettanomyces bruxellensis in wine by PCR targeting the vinylphenol reductase gene. LWT-Food Science and Technology. 2021. 136. 110321. doi: 10.1016/j.lwt.2020.110321.

o   Belda I, Gobbi A, Ruiz J, de Celis M, Ortiz-Álvarez R, Acedo A, Santos A. Microbiomics to Define Wine Terroir. In: Cifuentes, A. (Ed.) Comprehensive Foodomics. Reference Module in Food Science. 2021; vol. 3, 438-451. doi: 10.1016/B978-0-08-100596-5.22875-8. ISBN: 9780128163955.


o   Ruiz, J., de Celis, M., de Toro, M., Mendes-Ferreira, A., Rauhut, D., Santos, A., Belda, I. Phenotypic and transcriptional analysis of Saccharomyces cerevisiae during wine fermentation in response to nitrogen nutrition and co-inoculation with Torulaspora delbrueckii. Food Research International. 2020. 137, 109663. 10.1016/j.foodres.2020.109663.

o   Vicente J, Ruiz J, Belda I, Benito-Vázquez I, Marquina D, Calderon F, Santos A, Benito S. The genus Metschnikowia in enology. Microorganisms. 2020.  8, 1038; doi:10.3390/microorganisms8071038.

o   R. Velasco-Bucheli, D. Hormigo, J. Fernández-Lucas, P. Torres-Ayuso, Y. Alfaro-Ureña, A. I. Saborido, L. Serrano-Aguirre, J.L. García, F. Ramón, C. Acebal, A. Santos, M. Arroyo, I. de la Mata. Penicillin acylase from Streptomyces lavendulae and aculeacin A acylase from Actinoplanes utahensis: two versatile enzymes as useful tools for quorum quenching processes. Catalysts. 2020;  10, 730. doi: 10.3390/catal10070730.

o   de Celis M, Belda I, Ortiz-Álvarez R, Arregui L, Marquina D, Serrano S, Santos A. Tuning up microbiome analysis to monitor WWTPs' biological reactors functioning. Scientific Reports. 2020; 10(1):4079. doi: 10.1038/s41598-020-61092-1.

o   Vicente J, Alonso A, Navascués E, Marquina D, Santos A. Specific and sensitive PCR detection of Cadophora luteo-olivacea associated with grapevine trunk diseases. Crop Protection. 2020; 132: 105140. doi: 10.1016/j.cropro.2020.105140.


o   Gómez-Gómez B, Arregui L, Serrano S, Santos A, Pérez-Corona T, Madrid Y. Unravelling mechanisms of bacterial quorum sensing disruption by metal-based nanoparticles. Science of the Total Environment. 2019; 696:133869. doi: 10.1016/j.scitotenv.2019.133869.

o   Belda I, Ruiz J, Santos A, Van Wyk N, Pretorius IS. Saccharomyces cerevisiae. Trends in Genetics. 2019; 35(12):956-957. doi: 10.1016/j.tig.2019.08.009.

o   Alonso A, de Celis, M, Ruiz J, Vicente J, Navascués E, Acedo A, Ortíz-Alvarez R, Belda I, Santos A, Gómez-Flechoso M.A., Marquina D. Looking at the origin: Some insigths into the general and fermentative microbiota of vineyard soils. Fermentation. 2019. 5, 78. doi: 10.3390/fermentation5030078

o   Ruiz J, Ortega N, Martín-Santamaría M, Acedo A, Marquina D, Pascual O, Rozès N, Zamora F, Santos A, Belda I. Occurrence and enological properties of two new non-conventional yeasts (Nakazawaea ishiwadae and Lodderomyces elongisporus) in wine fermentations. International Journal of Food Microbiology. 2019; 305:108255. doi: 10.1016/j.ijfoodmicro.2019.108255.

o   Ruiz J, Kiene F, Belda I, Fracassetti D, Marquina D, Navascués E, Calderón F, Benito A, Rauhut D, Santos A, Benito S. Effects on varietal aromas during wine making: a review of the impact of varietal aromas on the flavor of wine. Applied Microbiology and Biotechnology. 2019; 103(18):7425-7450. doi: 10.1007/s00253-019-10008-9.

o   Gómez-Gómez B, Arregui L, Serrano S, Santos A, Pérez-Corona T, Madrid Y. Selenium and tellurium-based nanoparticles as interfering factors in quorum sensing-regulated processes: violacein production and bacterial biofilm formation. Metallomics. 2019; 11(6):1104-1114. doi: 10.1039/c9mt00044e.

o   de Celis M, Ruiz J, Martín-Santamaría M, Alonso A, Marquina D, Navascués E, Gómez-Flechoso MÁ, Belda I, Santos A. Diversity of Saccharomyces cerevisiae yeasts associated to spontaneous and inoculated fermenting grapes from Spanish vineyards. Letters in Applied Microbiology. 2019; 68(6):580-588. doi: 10.1111/lam.13155.


o   Ruiz J, Belda I, Beisert B, Navascués E, Marquina D, Calderón F, Rauhut D, Santos A, Benito S. Analytical impact of Metschnikowia pulcherrima in the volatile profile of Verdejo white wines. Applied Microbiology and Biotechnology.  2018; 102(19):8501-8509. doi: 10.1007/s00253-018-9255-3.

o   Soler A, Arregui L, Arroyo M, Mendoza JA, Muras A, Álvarez C, García-Vera C, Marquina D, Santos A, Serrano S. Quorum Sensing versus Quenching Bacterial Isolates Obtained from MBR Plants Treating Leachates from Municipal Solid Waste. fermentations. International Journal of Environmental Research in Public Health. 2018; 15(5). doi: 10.3390/ijerph15051019.


o   Belda I, Ruiz J, Beisert B, Navascués E, Marquina D, Calderón F, Rauhut D, Benito S, Santos A. Influence of Torulaspora delbrueckii in varietal thiol (3-SH and 4-MSP) release in wine sequential fermentations. International Journal of Food Microbiology. 2017; 257:183-191. doi: 10.1016/j.ijfoodmicro.2017.06.028.

o   Belda I, Zarraonaindia I, Perisin M, Palacios A, Acedo A. From Vineyard Soil to Wine Fermentation: Microbiome Approximations to Explain the “terroir” Concept. Frontiers in Microbiology. 2017; 8:821. doi: 10.3389/fmicb.2017.00821

o   Gutiérrez C, Gómez-Flechoso MÁ, Belda I, Ruiz J, Kayali N, Polo L, Santos A. Wine yeasts identification by MALDI-TOF MS: Optimization of the preanalytical steps and development of an extensible open-source platform for processing and analysis of an in-house MS database. International Journal of Food Microbiology. 2017; 254:1-10. doi: 10.1016/j.ijfoodmicro.2017.05.003.

o   Belda I, Ruiz J, Alonso A, Marquina D, Santos A. The Biology of Pichia membranifaciens Killer Toxins. Toxins (Basel). 2017; 9(4). doi: 10.3390/toxins9040112.

o   Belda I, Ruiz J, Esteban-Fernández A, Navascués E, Marquina D, Santos A, Moreno-Arribas MV. Microbial Contribution to Wine Aroma and Its Intended Use for Wine Quality Improvement. Molecules. 2017; 22(2). doi: 10.3390/molecules22020189.